Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

Conjugation of amide and lactam subunits by a ‘Click’ type approach provides access to structural mimics of the oxazolomycin series of natural products, some of which exhibit antibacterial activity.

Graphical abstractConjugation of lactams and amides by Click homologation gives bioactive mimics of oxazolomycin.Figure optionsDownload full-size imageDownload as PowerPoint slide