Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374533 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Novel 3-aminopyrrolidine derivatives were synthesized and evaluated for their antagonistic activity against human chemokine receptor 2. Structure–activity studies on 3-aminopyrrolidine incorporating heteroatomic carbocycle moieties led to piperidine compound 19, and piperazine compounds 42, 47 and 49 as highly potent hCCR2 antagonists.
Graphical abstract3-Aminopyrrolidine derivatives were synthesized and evaluated as potent chemokine receptor 2 (CCR2) antagonists.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jee Woong Lim, Youna Oh, Jong-Hoon Kim, Min-Ho Oak, Yongho Na, Jung-Ok Lee, Seung-Woo Lee, Heeyeong Cho, Woo-Kyu Park, Gildon Choi, Jongmin Kang,