| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374535 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
We report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4 receptor agonist. Compound 1 shows excellent erectogenic activity in the rodent models.
Graphical abstractWe report the design, synthesis and properties of spiroindane based compound 1, a potent, selective, orally bioavailable, non-peptide melanocortin subtype-4 receptor agonist. Compound 1 shows excellent erectogenic activity in the rodent models.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Shuwen He, Zhixiong Ye, Peter H. Dobbelaar, Iyassu K. Sebhat, Liangqin Guo, Jian Liu, Tianying Jian, Yingjie Lai, Christopher L. Franklin, Raman K. Bakshi, James P. Dellureficio, Qingmei Hong, Nancy N. Tsou, Richard G. Ball, Doreen E. Cashen,