| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374536 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The effect of essential oils, such as raspberry ketone, on androgen (AR) receptor was investigated using a MDA-kb2 human breast cancer cell line for predicting potential AR activity. Among them, eugenol had the highest AR antagonistic activity with its IC50 value of 19 μM. Raspberry ketone, which has threefold higher anti-obese activity than that of capsaicin, also had AR antagonist activity with its IC50 value of 252 μM. Based on these findings, a more precise CoMFA model was proposed as follows: pIC50 [log (1/IC50)] = 3.77 + [CoMFA field terms] (n = 39, s = 0.249, r2 = 0.834, scv = 0.507, q2 = 0.311 (three components).
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Related Topics
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Chemistry
Organic Chemistry
Authors
Yoshihisa Ogawa, Miki Akamatsu, Yudai Hotta, Akifumi Hosoda, Hiroto Tamura,