Synthesis and biological evaluations of novel bendazac lysine analogues as potent anticataract agents

Novel bendazac analogues and their salts have been designed and prepared. The resulting compounds (13c–d, 15c, 17c) showed very good aqueous solubility (>100 mg/mL). An in vitro assay showed that most of the resulting compounds had potent protective activity against the oxidative damage. Particularly, compound 13d was also able to enhance the WSP and T-AOC level in the H2O2/FeCl3-induced oxidative damage model, indicating the resulting compound may protect the lens through an antioxidant pathway.

Graphical abstractNovel bendazac analogues and their salts have been designed, prepared and biological evaluated. Most of the resulting compounds showed good aqueous solubility and had potent protective activity against the oxidative damage to isolated lenses.Figure optionsDownload full-size imageDownload as PowerPoint slide