| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374549 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Substituted pyridazino[4,5-b]indolizines were identified as potent and selective PDE4B inhibitors. We describe the structure–activity relationships generated around an HTS hit that led to a series of compounds with low nanomolar affinity for PDE4B and high selectivity over the PDE4D subtype.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Andrew F. Donnell, Paul J. Dollings, John A. Butera, Arlene J. Dietrich, Kerri K. Lipinski, Afshin Ghavami, Warren D. Hirst,