| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374556 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
Discovery of a series of pyrazolopiperidine sulfonamide based γ-secretase inhibitors and its SAR evolution is described. Significant increases in APP potency on the pyrazolopiperidine scaffold over the original N-bicyclic sulfonamide scaffold were achieved and this potency increase translated in an improved in vivo efficacy.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaocong M. Ye, Andrei W. Konradi, Jenifer Smith, Ying-Zi Xu, Darren Dressen, Albert W. Garofalo, Jennifer Marugg, Hing L. Sham, Anh P. Truong, Jacek Jagodzinski, Michael Pleiss, Hongbin Zhang, Erich Goldbach, John-Michael Sauer, Elizabeth Brigham,