| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374587 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
The identification of novel, potent, non-steroidal/small molecule functional GR antagonist GSK1564023A selective over PR is described. Associated structure–activity relationships and the process of optimisation of an initial HTS hit are also described.
Graphical abstractThe identification of novel, potent, non-steroidal/small molecule functional GR antagonist GSK1564023A PR is described. Associated structure–activity relationships and the process of optimisation of an initial HTS hit are also described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joseph Rimland, Angela Dunne, Suchete S. Hunjan, Rosemary Sasse, Iain Uings, Dino Montanari, Matilde Caivano, Poonam Shah, David Standing, David Gray, David Brown, William Cairns, Ryan Trump, Paul W. Smith, Nicolas Bertheleme, Pier D’Alessandro,