| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374608 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD4 contracted isolated human small airways ex-vivo. Several compounds demonstrated highly efficacious bronchorelaxing properties. Cinnamide 71 was selected for further studies and constitutes a promising candidate as a novel bronchorelaxing agent for the treatment of pulmonary disorders.
Graphical abstractThe discovery and synthesis of bronchodilator 71 using a functional tissue assay is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maria F. Dalence-Guzmán, Jörgen Toftered, Viveca Thornqvist Oltner, David Wensbo, Martin H. Johansson,