| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374630 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Synthesis and biological evaluation of jasplakinolide analogs are described. The synthesis of analogs utilized a diastereoselective syn-aldol reaction and an orthoester Claisen rearrangement as key steps. All synthetic analogs were evaluated for their ability to disrupt the actin cytoskeleton. Compounds 2, 3, and 4 essentially displayed similar activity to jasplakinolide.
Graphical abstractEight new jasplakinolide derivatives were synthesized and evaluated for antitumor activity by measuring their ability to interfere with the actin cytoskeleton. Simplified derivative 4 is essentially as active as natural jasplakinolide.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Arun K. Ghosh, Zachary L. Dawson, Deuk Kyu Moon, Ruoli Bai, Ernest Hamel,