| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374643 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
A series of novel benzimidazole derivatives has been designed via a scaffold morphing approach based on known calcilytics chemotypes. Subsequent lead optimisation led to the discovery of penta-substituted benzimidazoles that exhibit attractive in vitro and in vivo calcium-sensing receptor (CaSR) inhibitory profiles. In addition, synthesis and structure–activity relationship data are provided.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marc Gerspacher, Eva Altmann, René Beerli, Thomas Buhl, Ralf Endres, Rainer Gamse, Jacques Kameni-Tcheudji, Michaela Kneissel, Karl Heinz Krawinkler, Martin Missbach, Alfred Schmidt, Klaus Seuwen, Sven Weiler, Leo Widler,