Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374649 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
This communication describes the synthesis and in vitro biological evaluation of novel generation 5 PAMAM dendrimers conjugated with riboflavin as a targeting ligand. Cell-based experiments demonstrated that a dendrimer conjugated with riboflavin is able to undergo cellular binding and uptake in KB cells, and when the dendrimer is also conjugated with methotrexate, the riboflavin dendrimer conjugate can potently inhibit cell growth.
Graphical abstractThis communication describes the design and in vitro biological evaluation of novel generation 5 PAMAM dendrimers conjugated with riboflavin as a targeting ligand.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Thommey P. Thomas, Seok Ki Choi, Ming-Hsin Li, Alina Kotlyar, James R. Baker Jr.,