| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374652 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
N-Aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 which exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo.
Graphical abstractN-Aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. Compound 15 exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Francis Giraud, Pascal Marchand, Delphine Carbonnelle, Michael Sartor, François Lang, Muriel Duflos,