Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs

Herein we disclose the first total synthesis of tambjamine K and a library of unnatural analogs. Unnatural analogs were shown to be more potent in viability, proliferation, and invasion assays than the natural product in multiple cancer cell lines, with minimal to no cytotoxicity on non-transformed cell lines.

Graphical abstractThe first total synthesis of tambjamine K and a library of unnatural analogs is reported. Unnatural analogs were shown to be more potent in viability, proliferation, and invasion assays than the natural product in multiple cancer cell lines, with minimal to no cytotoxicity on non-transformed cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide