| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374659 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.
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Authors
Ahmed Kamal, J. Surendranadha Reddy, M. Janaki Ramaiah, E. Vijaya Bharathi, D. Dastagiri, M. Kashi Reddy, S.N.C.V.L. Pushpavalli, Manika Pal-Bhadra,