| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374670 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
Screening of our library of peroxisome proliferator-activated receptor (PPAR) agonists yielded several phenylpropanoic acid-derived γ-secretase inhibitors (GSIs). Structure–activity relationship studies indicated that (R)-configuration of α-substituted phenylpropanoic acid structure and cinnamic acid structure is favorable to prepare Notch-sparing GSIs.
Graphical abstractScreening of our library of peroxisome proliferator-activated receptor (PPAR) agonists yielded several phenylpropanoic acid-derived γ-secretase inhibitors (GSIs).Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Motonori Kurosumi, Yoshino Nishio, Satoko Osawa, Hisayoshi Kobayashi, Takeshi Iwatsubo, Taisuke Tomita, Hiroyuki Miyachi,