| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374680 | Bioorganic & Medicinal Chemistry Letters | 2010 | 5 Pages |
Abstract
A novel series of 2-aminobenzimidazole inhibitors of BACE1 has been discovered using fragment-based drug discovery (FBDD) techniques. The rapid optimization of these inhibitors using structure-guided medicinal chemistry is discussed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James Madden, Jenny R. Dod, Robert Godemann, Joachim Kraemer, Myron Smith, Marion Biniszkiewicz, David J. Hallett, John Barker, Jane D. Dyekjaer, Thomas Hesterkamp,