| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374685 | Bioorganic & Medicinal Chemistry Letters | 2010 | 4 Pages |
Abstract
New oxathiazinane dioxides have been derived from d- and l-serine and tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. (5R)-5-(4-(4′-Bromomethyl)phenyl)benzyloxymethyl-[1,3,4]-oxathiazinane-3,3-dioxide showed a cytotoxicity of IC50 ≈ 10 μM.
Graphical abstractNew oxathiazinane dioxides derived from d- and l-serine have been tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. Compound (R)-24 (R′ = BrCH2C6H4-C6H4CH2) showed a cytotoxicity with IC50 ≅ 10 μM.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Françoise Borcard, Matthias Baud, Claudia Bello, Giovanna Dal Bello, Francesco Grossi, Paolo Pronzato, Michele Cea, Alessio Nencioni, Pierre Vogel,