| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374695 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of heteroaromatic analogs of pregabalin has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.
Graphical abstractAs part of a program to identify the scope of substituents recognized by the α2-δ protein, a series of heteroaromatic analogs, 2, of pregabalin, 1, has been identified that possess anticonvulsant activity in the DBA/2 mouse model. The methods of synthesis and preliminary pharmacology are discussed herein.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Robert M. Schelkun, Po-wai Yuen, David J. Wustrow, Jack Kinsora, Ti-Zhi Su, Mark G. Vartanian,