| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374700 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
A new structurally simple series of potent lipophilic aza-retinoids RXR agonists has been developed. SAR studies for the N-alkyl-azadienoic acids described here demonstrate that the RXR activity profile is sensitive to the N-alkyl chain length. Further, we have expanded the work to include azadienoic acids, which exhibited many accessible conformations leading to a better understanding of the SAR around the series.
Graphical abstractA new structurally simple series of potent lipophilic aza-retinoid RXR agonists has been developed. SAR studies for the N-alkyl-azadienoic acids described here demonstrate that the RXR activity profile is sensitive to the N-alkyl chain length. Further, we have expanded the work to include azadienoic acids, which exhibited many accessible conformations leading to a better understanding of the SAR around the series.Figure optionsDownload full-size imageDownload as PowerPoint slide
