Cespitulactones A and B, new diterpenoids from Cespitularia taeniata

Two new diterpenoids, designated cespitulactones A (1) and B (2), were isolated from a sample of the soft coral Cespitularia taeniata collected in Taiwan. Compound 1 possesses a novel structure with a bond cleavage between C-10 and C-11, and having a 14-membered lactone ring junction between C-10 and C-12. Their structures were elucidated on the basis of extensive spectroscopic analysis and chemical derivatization. The isolated compounds were also evaluated for cytotoxicity toward human cancer cell lines.

Graphical abstractTwo new diterpenoids, designated cespitulactones A (1) and B, were isolated from Cespitularia taeniata collected in Taiwan.Figure optionsDownload full-size imageDownload as PowerPoint slide