A practical and green approach towards synthesis of dihydropyrimidinones: Using heteropoly acids as efficient catalysts

A simple and green chemistry procedure for the synthesis of dihydropyrimidinones using heteropoly acid mediated cyclocondensation reaction is described. This method provides an efficient and much improved modification of the original Biginelli reaction reported in 1893, in terms of high yields, and short reaction times. It has the ability to allow a wide variety of substitutions in all three components.

Graphical abstractOne-pot synthesis of dihydropyrimidones catalyzed by heteropoly acids as efficient, inexpensive, easily available and environmentally friendly catalysts. High to excellent yields, short reaction times and compatibility with various functional groups are features of this new procedure.Figure optionsDownload full-size imageDownload as PowerPoint slide