| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374738 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Leukotriene biosynthesis inhibitors have potential as therapeutic agents for asthma and inflammatory diseases. A novel series of substituted coumarin derivatives has been synthesized and the structure–activity relationship was evaluated with respect to their ability to inhibit the formation of leukotrienes via the human 5-lipoxygenase enzyme.
Graphical abstractA novel series of substituted coumarin derivatives has been synthesized. SAR studies in this series led to the identification of inhibitor 1.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Erich L. Grimm, Christine Brideau, Nathalie Chauret, Chi-Chung Chan, Daniel Delorme, Yves Ducharme, Diane Ethier, Jean-Pierre Falgueyret, Richard W. Friesen, Jocelyne Guay, Pierre Hamel, Denis Riendeau, Chantal Soucy-Breau, Philip Tagari, Yves Girard,