| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374760 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
β-C-Glycosiduronic acid quinones and β-C-glycosyl compounds have been synthesized as sugar-based PTP1B inhibitors. Benzoyl protected quinone derivatives (14 and 35) as well as aryl β-C-glycosyl compounds (18, 22, 23 and 34) showed IC50 values of 0.77–5.27 μM against PTP1B, with compounds 18 and 23 bearing an acidic function being the most potent.
Graphical abstractBenzoyl protected β-C-glycosyl compounds inhibitent PTP1B with IC50 in micromolar range.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Li Lin, Qiang Shen, Guo-Rong Chen, Juan Xie,