| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374766 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Efforts towards developing orally bioavailable HIV-1 maturation inhibitors starting from betulinic acid 1 are described. SAR resulted in improved potency, physicochemical properties, and enhanced oral absorption in rats.
Graphical abstractEfforts towards developing orally bioavailable HIV-1 maturation inhibitors starting from betulinic acid 1 are described. SAR resulted in improved potency, physicochemical properties, and enhanced oral absorption in rats.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David Gerrish, In Chul Kim, Dange V. Kumar, Harry Austin, Jennifer E. Garrus, Vijay Baichwal, Michael Saunders, Rena S. McKinnon, Mark B. Anderson, Robert Carlson, Esther Arranz-Plaza, Kraig M. Yager,