| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374768 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBKα channels. Oxime ether structure on the B ring of diCl-DHAA significantly increased the BK channel-opening activity.
Graphical abstractThe oxime ether structure, particularly when bearing O-short carbon chains, significantly increased the BK channel-opening activity of 12,14-dichlorodehydroabietic acid (4b).Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yong-Mei Cui, Eriko Yasutomi, Yuko Otani, Takashi Yoshinaga, Katsutoshi Ido, Kohei Sawada, Masatoshi Kawahata, Kentaro Yamaguchi, Tomohiko Ohwada,