| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374771 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A novel 6,14-epoxymorphinan benzamide derivative (NS22) was synthesized, which showed opioid κ receptor agonistic activity in the [35S]GTPγS binding assay. The antinociceptive effect of NS22 was evaluated in the tail-flick and the hot-plate test. This compound showed a potent antinociceptive activity in mice by sc administration, which was attenuated with nor-BNI (selective opioid κ receptor antagonist).
Graphical abstractThe antinociceptive effect of NS22 was evaluated in the tail-flick and the hot-plate test. NS22 showed a potent antinociceptive activity in mice (sc), which was attenuated with nor-BNI.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Toru Nemoto, Hideaki Fujii, Minoru Narita, Kan Miyoshi, Atsushi Nakamura, Tsutomu Suzuki, Hiroshi Nagase,