| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374774 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
A novel water soluble and biodegradable cyclotriphosphazene–paclitaxel conjugate was prepared by reacting 2′-succinyl paclitaxel with cyclotriphosphazenes bearing equimolar glycyl-l-lysine and methoxy poly(ethylene glycol) as side groups. The macromolecular conjugate was found to self-assemble in aqueous solution to form stable micelles with a mean hydrodynamic diameter of 24.7 nm and a low critical micelle concentration of 10 mg/L. The present conjugate exhibited lower than free paclitaxel but reasonably high in vitro cytotoxicity against selected human tumor cells due to their hydrolytic degradation in PBS solution.
Graphical abstractA novel biodegradable micelle-forming cyclotriphosphazene–paclitaxel conjugate was synthesized.Figure optionsDownload full-size imageDownload as PowerPoint slide
