| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374776 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A novel series of butadiene-imide 1 (T-686) derivatives having an inhibitory activity against PAI-1 production was synthesized and evaluated their biological activities and DMPK profiles, in which 15k (T-2639) was selected as the best compound based on its strong antithrombotic activity and good bioavailability.
Graphical abstractThe design, synthesis, and evaluation of T-2639, orally active inhibitor of PAI-1 production, is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroshi Miyazaki, Tsuyoshi Ogiku, Hiroshi Sai, Hiroshi Ohmizu, Jun Murakami, Akio Ohtani,