Identification of small molecule agonists of the motilin receptor

High-throughput screening resulted in the identification of a series of novel motilin receptor agonists with relatively low molecular weights. The series originated from an array of biphenyl derivatives designed to target 7-transmembrane (7-TM) receptors. Further investigation of the structure–activity relationship within the series resulted in the identification of compound (22) as a potent and selective agonist at the motilin receptor.

Graphical abstractHigh-throughput screening resulted in the identification of a series of novel motilin receptor agonists with relatively low molecular weights. The series originated from an array of biphenyl derivatives designed to target 7-transmembrane (7-TM) receptors. Further investigation of the structure–activity relationship within the series resulted in the identification of compound (22) as a potent and selective agonist at the motilin receptor.Figure optionsDownload full-size imageDownload as PowerPoint slide