| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374781 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Structure–activity relationships and efforts to optimize the pharmacokinetic profile of isosteric analogs of 2-arylimino-5,6-dihydro-4H-1,3-thiazines as cannabinoid receptor agonists are described. Among those examined, compound 25 showed potent affinity for cannabinoid receptor 1 (CB1) and receptor 2 (CB2). This compound displayed oral bioavailability and analgesic activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiroyuki Kai, Yasuhide Morioka, Yuji Koriyama, Kazuya Okamoto, Yasushi Hasegawa, Maki Hattori, Katsumi Koike, Hiroki Chiba, Shunji Shinohara, Yuka Iwamoto, Kohji Takahashi, Norihiko Tanimoto,