Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones

Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80–96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger.

Graphical abstractThe synthesis of dihydropyridines under solvent-free conditions catalyzed by cupric chloride and their antifungal activities are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide