Article ID Journal Published Year Pages File Type
1374793 Bioorganic & Medicinal Chemistry Letters 2008 4 Pages PDF
Abstract

A series of helicid analogues were synthesized and evaluated as tyrosinase inhibitors. The results demonstrated that some compounds had more potent inhibitory activities than arbutin (IC50 7.3 mM). In particular, compound 1c bearing 4,6-O-benzylidene substituent on the sugar moiety was found to be the most potent inhibitor with IC50 value of 0.052 mM. The inhibition kinetics analyzed by Lineweaver–Burk plots revealed that helicid analogues were competitive inhibitors. The Circular dichroism spectra indicated that those compounds induced conformational changes of mushroom tyrosinase upon binding.

Graphical abstractA series of helicid analogues were synthesized and their inhibitory activities on the diphenolase activity of mushroom tyrosinase were investigated. Compound 1c was found to be the most potent compound with IC50 value of 0.052 mΜ.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Physical Sciences and Engineering Chemistry Organic Chemistry
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