| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374858 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A series of indeno[1,2-c]pyrazoles were discovered to be the first known inhibitors of heme-regulated eukaryotic initiation factor 2α (HRI) kinase. The synthesis, structure–activity relationship profile, and in-vitro pharmacological characterization of this inaugural series of HRI kinase inhibitors are detailed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark D. Rosen, Craig R. Woods, Steven D. Goldberg, Michael D. Hack, A. Dawn Bounds, Young Yang, Pamela C. Wagaman, Victor K. Phuong, Angela P. Ameriks, Terrance D. Barrett, Kimon C. Kanelakis, Jui Chang, Nigel P. Shankley, Michael H. Rabinowitz,