| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374860 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
Human Lyn tyrosine kinase is expressed in hematopoietic tissues and plays crucial roles in the signal transduction of hematopoietic immune system. Its excess activity is involved in several tumors. The crystal structure has revealed that the potent inhibitor staurosporine binds to human Lyn kinase domain at the ATP-binding site. The remarkable structural features of the staurosporine-binding region will offer valuable structural insights for the structure-based design of novel Lyn-selective inhibitors.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nao Miyano, Takayoshi Kinoshita, Ryoko Nakai, Yasuyuki Kirii, Koichi Yokota, Toshiji Tada,