| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374865 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
2-Amino-5-aryl-pyridines, exemplified by compound 1, had been identified as a synthetically tractable series of CB2 agonists from a high-throughput screen of the GlaxoSmithKline compound collection. Described herein are the results of an investigation of the structure–activity relationships (SAR) which led to the identification a number of potent and selective agonists.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Robert J. Gleave, Paul J. Beswick, Andrew J. Brown, Gerard M.P. Giblin, Carl P. Haslam, David Livermore, Andrew Moses, Neville H. Nicholson, Lee W. Page, Brian Slingsby, Martin E. Swarbrick,