| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374871 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
In the recent past sugar-derived cyclopropylamines were proposed as structurally new glycosidase inhibitors. In this Letter we report our efforts in the synthesis of a set of α-glucose configured oxabicyclo[4.1.0] heptanes, based on this hypothesis, bearing an amine substituent on the propyl ring and reveal that their inhibitory potential towards a range of mammalian glucosidases is modest.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Martijn D.P. Risseeuw, Richard J.B.H.N. van den Berg, Wilma E. Donker-Koopman, Gijs A. van der Marel, Johannes M.F.G. Aerts, Mark Overhand, Herman S. Overkleeft,