| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374874 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
Biaryl purine derivatives such as 2 have demonstrated inhibition of cyclin dependent kinases and potent antiproliferative activity. Replacement of the C-6 biarylmethylamino group with heterobiarylmethylamino groups has afforded compounds such as 18g and 9c with significantly improved in vitro activity.
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Authors
Michael P. Trova, Keith D. Barnes, Luis Alicea, Travis Benanti, Mark Bielaska, Joseph Bilotta, Brian Bliss, Thuy Nguyen Duong, Simon Haydar, R. Jason Herr, Yu Hui, Matthew Johnson, John M. Lehman, Denise Peace, Matthew Rainka, Patricia Snider,