| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374876 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
A high-throughput cell-based screen identified a series of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of metabotropic glutamate receptor 5 (mGlu5). This Letter describes the SAR of this series and the profile of selected compounds in selectivity and radioligand binding assays.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew S. Felts, Sam A. Saleh, Uyen Le, Alice L. Rodriguez, C. David Weaver, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte,