Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1374887 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
5-(4-Aminophenyl)-10,15,20-tris(4-sulfonatophenyl) manganese(III) porphyrin conjugated with dextran was synthesized. Its potential of being used as a tumor-targeting magnetic resonance imaging contrast agent was evaluated in vitro and in vivo. The results demonstrated that the compound has a longitudinal relaxivity (R1) higher than Gd-DTPA, low cytotoxicity and binding specificity to tumor cell membrane.
Graphical abstractThe synthesis and evaluation of Mn porphyrin–dextran as MRI contrast agents are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhi Zhang, Rui He, Kun Yan, Qian-ni Guo, Yun-guo Lu, Xu-xia Wang, Hao Lei, Zao-ying Li,