| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374907 | Bioorganic & Medicinal Chemistry Letters | 2009 | 4 Pages |
Abstract
New classes of de novo designed renin inhibitors are reported. Some of these compounds display excellent in vitro and in vivo activities toward human renin in a TGR model. The synthesis of these new types of mono- and bicyclic scaffolds are reported, and properties of selected compounds discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
L’uboš Remeň, Olivier Bezençon, Sylvia Richard-Bildstein, Daniel Bur, Lars Prade, Olivier Corminboeuf, Christoph Boss, Corinna Grisostomi, Thierry Sifferlen, Panja Strickner, Patrick Hess, Stéphane Delahaye, Alexander Treiber, Thomas Weller,