| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374916 | Bioorganic & Medicinal Chemistry Letters | 2009 | 5 Pages |
Abstract
A class of novel 2-aminobenzothiazoles have been identified as NPY Y1 antagonists. Various N-heterocyclic substituted aminophenethyl-2-aminobenzothiazole analogs were synthesized to explore the SAR. Isothiourea analogs and ligands with high potency (Ki 30 nM) have been identified.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhong-Yue Sun, Zhaoning Zhu, Yuanzan Ye, Brian McKittrick, Michael Czarniecki, William Greenlee, Deborra Mullins, Mario Guzzi,