| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374933 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of heterocycle-containing oxindoles was synthesized and their HIV antiviral activities were assessed. Some of these analogs exhibited potent inhibitory activities against both wild-type virus and a number of drug-resistant mutant viruses. In addition, oxindole 9z also showed promising pharmacokinetics.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tao Jiang, Kelli L. Kuhen, Karen Wolff, Hong Yin, Kimberly Bieza, Jeremy Caldwell, Badry Bursulaya, Tove Tuntland, Kanyin Zhang, Donald Karanewsky, Yun He,