Synthesis of Pseudomonas quorum-sensing autoinducer analogs and structural entities required for induction of apoptosis in macrophages

The synthesis of the analogs of N-3-oxododecanoyl-l-homoserine lactone (1) and their structure–activity relationship for the apoptotic induction in macrophages, P388D1 cells, are described. It was revealed that the position of the oxo group in the acyl side chain in addition to the presence of the l-homoserine lactone unit is crucial for the apoptosis-inducing activity. Furthermore, the long acyl side chains with hydrophobic distal ends are preferable for the activity.

Graphical abstractSynthesis of analogs of Pseudomonas quorum-sensing autoinducer, N-3-oxododecanoyl-l-homoserine lactone (1) and their structure–activity relationship for the apoptosis induction in macrophages are described.Figure optionsDownload full-size imageDownload as PowerPoint slide