| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374941 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Esters of 1-(H)-imidazole-5-nitrolic acid and 1-methyl-imidazole-5-carboxamide oxime were prepared to study the effect of esterification on the ocular effects of these compounds. Esterifications were performed with acid chloride. Acid chloride also reacts with the ring nitrogen of 1-(H)-imidazole-5-nitrolic acid, but the desired esters could be selectively prepared by adjustment of the reaction conditions. Esterification led to loss of the ocular effects exhibited by the parent compounds.
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Authors
Larisa Oresmaa, Hanna Kotikoski, Matti Haukka, Olli Oksala, Esko Pohjala, Heikki Vapaatalo, Pirjo Vainiotalo, Paula Aulaskari,