| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374950 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
The design and synthesis of four 2,2-disubstituted dihydrobenzofurans that are structurally related to several glutamate-containing natural products, including (−)-dysiherbaine, is described. Biological evaluation of these analogs shows that one is a KA receptor antagonist and another is an NMDA receptor agonist.
Graphical abstractThe design, synthesis, and iGluR activity of a series of 2,2-disubstituted dihydrobenzofurans that are structurally related to several glutamate containing natural products, including (−)-dysiherbaine, is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jamie L. Cohen, Agenor Limon, Ricardo Miledi, A. Richard Chamberlin,