| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374955 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Twenty-six thiosemicarbazones (III-1–III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. The testing of anticancer activity of these compounds in vitro against P-388, A-549, and SGC-7901 shows that compounds III-15 and III-16 possess a higher inhibitory ability for P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 μM.
Graphical abstractTwenty-six thiosemicarbazones (III-1–III-26) were synthesized via three steps starting from hydrazine hydrate and carbon disulfide. Their anticancer activities in vitro were evaluated. It shows that compounds III-15 and III-16 possess a higher inhibitory ability against P-388 and SGC-7901. Further testing shows that the value of IC50 of compound III-16 against SGC-7901 reaches to 0.032 μM.Figure optionsDownload full-size imageDownload as PowerPoint slide
