| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374958 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid) receptor ligands to image brain diseases. The single crystal structure of the most potent compound N-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (5a) is first reported.
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Related Topics
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Organic Chemistry
Authors
Mingzhang Gao, Deyuan Kong, Abraham Clearfield, Qi-Huang Zheng,