| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1374961 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Efforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.
Graphical abstractEfforts to improve the potency and pharmacokinetic properties of small molecule factor VIIa inhibitors are described. Small structural modifications to existing leads allow the modulation of half-life and clearance, potentially making these compounds suitable candidates for drug development.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Aleksandr Kolesnikov, Roopa Rai, Wendy B. Young, Joyce Mordenti, Liang Liu, Steven Torkelson, William D. Shrader, Ellen M. Leahy, Huiyong Hu, Erik Gjerstad, James Janc, Bradley A. Katz, Paul A. Sprengeler,