Article ID Journal Published Year Pages File Type
1374965 Bioorganic & Medicinal Chemistry Letters 2006 6 Pages PDF
Abstract

A novel series of potent blockers of the monocarboxylate transporter, MCT1, is disclosed. From very potent but lipophilic lead compounds, systematic changes to all parts of the molecule, targeting reduction in log D, afforded compounds with significantly improved overall properties. These compounds show potent immunomodulatory activity.

Graphical abstractThe synthesis and properties of a novel series of potent blockers of the monocarboxylate transporter, MCT1, are described. These compounds, exemplified by 30, show potent immunomodulatory activity.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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